Live Donors of the Initial Observational Study of Uterus Transplantation-Psychological and Medical Follow-Up Until 1 Year After Surgery in the 9 Cases

Transplantation. 2017 Mar;101(3):664-670. doi: 10.1097/TP.0000000000001567.


Background: The first prospective observational study of uterus transplantation was initiated in 2013 with live donation to 9 women with absolute uterine factor infertility. We explored the medical complications and psychosocial wellbeing of the donors during the first postoperative year.

Methods: Complications were registered and graded according to the Clavien-Dindo (C-D) classification. Symptoms related to the surgery were registered. Data on length of hospital stay, sick leave, socioeconomic parameters, and life events were obtained. Psychological evaluations (Psychological General Well-Being, Dyadic Adjustment Scale, Hospital Anxiety and Depression Scale [HADS], SF-36) questionnaires focusing on quality of life, mood, and relationship, were conducted at inclusion and at 3, 6, and 12 months after uterus donation.

Results: One major surgical complication (C-D IIIb) occurred. A ureteric-vaginal fistula developed 2 weeks after uterus procurement. The fistula was surgically repaired. Two self-reported and transient complications (C-D I) were noted (nocturia, meralgia paresthetica). Hospital stays of all donors were 6 days and median sick leave was 56 days (range, 14-132). At inclusion, median scores exceeded the normative values of the Swedish population in Psychological General Well-Being and Dyadic Adjustment Scale. HADS-Anxiety was detected preoperatively in 1 donor. Two donors exceeded 10-point declines in SF-36 summary scores and increased their HADS scores by 6 points during the observation period. All donors returned to their predonation levels of physical health.

Conclusions: The results support that it is feasible to retrieve a uterus safely from a live donor. Further studies are needed to better evaluate the method.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Female
  • Fertility
  • Follow-Up Studies
  • Humans
  • Hysterectomy / adverse effects
  • Hysterectomy / psychology*
  • Infertility, Female / diagnosis
  • Infertility, Female / physiopathology
  • Infertility, Female / psychology
  • Infertility, Female / surgery*
  • Length of Stay
  • Life Change Events
  • Living Donors / psychology*
  • Mental Health*
  • Middle Aged
  • Organ Transplantation / adverse effects
  • Organ Transplantation / methods
  • Organ Transplantation / psychology*
  • Postoperative Complications / etiology
  • Postoperative Complications / psychology
  • Postoperative Complications / surgery
  • Psychiatric Status Rating Scales
  • Quality of Life*
  • Reoperation
  • Retrospective Studies
  • Risk Factors
  • Sick Leave
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Sweden
  • Time Factors
  • Treatment Outcome
  • Uterus / pathology
  • Uterus / physiopathology
  • Uterus / transplantation*