Fundamental Characteristics of the Newly Developed ATA™ Membrane Dialyzer

Contrib Nephrol. 2017:189:215-221. doi: 10.1159/000451044. Epub 2016 Dec 12.

Abstract

Background: Dialysis membranes are often made from synthetic polymers, such as polysulfone. However, membranes made from cellulose triacetate have superior biocompatibility and have been used since the 1980s. On-line hemodiafiltration treatment accompanied by massive fluid replacement is increasingly being used in Europe and Japan, but cellulose triacetate is not suitable for this treatment.

Summary: Our newly developed asymmetric triacetate membrane, the ATA™ membrane, substantially improved the filtration properties and blood compatibility because of the asymmetric structure and smooth surface of this cellulose acetate membrane. Key Message: The ATA membrane maintains its high permeability even after massive filtration and shows less temporal variation in its permeation performance, lower protein adsorption, and superior biocompatibility compared with conventional membranes.

Publication types

  • Review

MeSH terms

  • Adsorption
  • Biocompatible Materials
  • Cellulose / analogs & derivatives
  • Humans
  • Membranes, Artificial*
  • Permeability
  • Renal Dialysis / instrumentation*

Substances

  • Biocompatible Materials
  • Membranes, Artificial
  • Cellulose
  • cellulose triacetate