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. 2017 Mar;137(3):546-549.
doi: 10.1016/j.jid.2016.10.024. Epub 2016 Dec 9.

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal

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Free PMC article

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal

Jason E Hawkes et al. J Invest Dermatol. .
Free PMC article

Abstract

Since 2009, the imiquimod- or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of acute skin inflammation has become the most widely used mouse model in preclinical psoriasis studies. Although this model offers researchers numerous benefits, there are important limitations and possible confounding variables to consider. The imiquimod model requires careful consideration and warrants scrutiny of the data generated by its use. In this perspective, we provide an overview of the advantages and disadvantages of this mouse model and offer suggestions for its use in psoriasis research.

Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

Figure 1
Figure 1. IMQ publication trend since 2009
Trend in the number of publications involving the use of the imiquimod-induced mouse model of skin inflammation between its initial description in 2009 and October 2016.
Figure 2
Figure 2. Representative histologic images of the skin from C57BL/6 mice
Routine hematoxylineosin staining of (a) untreated wild-type skin, (b) imiquimod-treated skin, and (c) tangentially sectioned imiquimod-treated skin showing artificially increased acanthosis in the center of the specimen (original magnifications ×100). Scale bar in a = 100 μm.

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