Modulation of reward-related neural activation on sensation seeking across development

Neuroimage. 2017 Feb 15;147:763-771. doi: 10.1016/j.neuroimage.2016.12.020. Epub 2016 Dec 9.

Abstract

Sensation seeking is a personality construct associated with an increased propensity for engaging in risk-taking. Associations with deleterious outcomes ranging from mental health impairments to increased mortality rates highlight important public health concerns related to this construct. Although some have suggested that increased neural responsivity to reward within the ventral striatum (e.g., nucleus accumbens) may drive sensation seeking behaviors, few studies have examined the neural mechanisms associated with stable individual differences in sensation seeking across development. To address this issue, the current study used functional magnetic resonance imaging to examine the association between neural responding to reward and stable patterns of sensation seeking across a three-year follow-up period among healthy adolescents and young adults (N = 139). Results indicated that during early adolescence (~ages 10-12), increased reactivity to reward within the nucleus accumbens (NAcc) was associated with lower levels of sensation seeking across a three-year follow-up. In middle adolescence (~ages 12-16), there was no evidence of a relationship between NAcc reactivity and sensation seeking. However, during the transition from late adolescence into adulthood (~ages 17-25), heightened reward-related reactivity in the NAcc was linked to increased sensation seeking. Findings suggest that the neural mechanisms underlying individual differences in trait-like levels of sensation seeking change from early to late adolescence.

Keywords: Development; Reward; Sensation seeking; fMRI.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Exploratory Behavior / physiology*
  • Eye Movement Measurements
  • Female
  • Follow-Up Studies
  • Human Development / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Nucleus Accumbens / diagnostic imaging
  • Nucleus Accumbens / physiology*
  • Personality / physiology*
  • Reward*
  • Risk-Taking*
  • Task Performance and Analysis
  • Young Adult