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Case Reports
. 2010 Apr;3(2):96-98.
doi: 10.4021/gr2010.04.181w. Epub 2010 Mar 20.

Erythema Annulare Centrifugum: A Rare Skin Finding of Autoimmune Hepatitis

Free PMC article
Case Reports

Erythema Annulare Centrifugum: A Rare Skin Finding of Autoimmune Hepatitis

Cem Aygun et al. Gastroenterology Res. .
Free PMC article


Erythema annulare centrifugum is characterized by dermal perivascular lymphocytic infiltrates. It is often associated with infections, autoimmune or neoplastic diseases but in most cases the cause is unexplained. A case of erythema annulare centrifugum related to autoimmune hepatitis in a 24-year-old woman is described in this case report. Clinical response of the autoimmune hepatitis to a combination therapy with corticosteroids and azothiopurine was achieved. Although partially regressed for the first 12 months of theraphy, the skin lesions did not disappear completely. However, after 18 months of continious treatment there was no skin lesion.

Keywords: Autoimmune hepatitis; Erythema annulare centrifugum.


Figure 1
Figure 1
Erythematous lesion on the abdominal wall of patient. Skin changes started over the shoulder region initially, they were intermittent and not cosmetically disturbing, but after 2 months with the onset of overt autoimmune hepatitis, a larger and cosmetically disturbing EAC lesion developed.
Figure 2
Figure 2
Histopathologic examination of the lesion showed diffuse perivascular infiltrate in the dermis (Haematoxylin & Eosin, x100).

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