To PFKFB3 or Not to PFKFB3, That Is the Question

Cancer Cell. 2016 Dec 12;30(6):831. doi: 10.1016/j.ccell.2016.11.007.


In this issue of Cancer Cell, Cantelmo et al. describe how reduction of PFKFB3 enzyme activity can promote vascular normalization. The authors show in turn how this affects vascular permeability and can ultimately improve the efficacy of chemotherapeutic agents.

MeSH terms

  • Antineoplastic Agents*
  • Humans
  • Phosphofructokinase-2*


  • Antineoplastic Agents
  • Phosphofructokinase-2