Potential hypoglycaemic activity phenolic glycosides from Moringa oleifera seeds

Nat Prod Res. 2017 Aug;31(16):1869-1874. doi: 10.1080/14786419.2016.1263846. Epub 2016 Dec 14.


Moringa oleifera seed has remarkable curative effects on reducing blood pressure, blood sugar and enhancing human immunity. In this study, one novel phenolic glycoside (1) together with four known compounds 2-5 were isolated from the macroporous resin adsorption extract of M. oleifera seeds, and the compound 3 was reported for the first time from this plant. The structure of the new crystalline compound was determined on the basis of spectroscopic analyses including mass spectrometry, 1D and 2D NMR experiments. The hypoglycaemic activity of isolated compounds was investigated with HepG2 cell and STZ-induced mice. It was found that compound 1, 4 and 5 could promote the glucose consumption of insulin resistance cells and reduce blood glucose levels of STZ-induced mice. This study concludes that compound 1, 4 and 5 may be developed as new and safe hypoglycaemic drugs.

Keywords: HepG 2 cell; Moringa oleifera; hypoglycemic activity; phenolic glycoside.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Experimental / drug therapy
  • Drug Evaluation, Preclinical / methods
  • Glycosides / chemistry
  • Glycosides / pharmacology*
  • Hep G2 Cells
  • Humans
  • Hypoglycemic Agents / chemistry*
  • Hypoglycemic Agents / pharmacology*
  • Insulin Resistance
  • Magnetic Resonance Spectroscopy
  • Mice, Inbred ICR
  • Molecular Structure
  • Moringa oleifera / chemistry*
  • Phenols / chemistry
  • Phenols / pharmacology
  • Plant Extracts / chemistry
  • Seeds / chemistry


  • Blood Glucose
  • Glycosides
  • Hypoglycemic Agents
  • Phenols
  • Plant Extracts