Induction of specific-locus and dominant lethal mutations in male mice by chlormethine

Mutat Res. 1989 Oct;227(2):81-9. doi: 10.1016/0165-7992(89)90002-x.

Abstract

Chlormethine (WHO), a nitrogen mustard (2,2'-dichloro-N-methyldiethylamine), induces dominant lethal and specific-locus mutations in spermatozoa and spermatids of mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Crosses, Genetic
  • Female
  • Genes, Dominant
  • Genes, Lethal
  • Male
  • Mechlorethamine / toxicity*
  • Mice
  • Mutagens*
  • Spermatozoa / drug effects

Substances

  • Mutagens
  • Mechlorethamine