A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

Nature. 1989 Oct 12;341(6242):508-13. doi: 10.1038/341508a0.


The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • Drosophila / embryology
  • Drosophila / genetics*
  • Embryo, Nonmammalian / physiology
  • Genes*
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Protein Conformation
  • Restriction Mapping


  • Membrane Proteins
  • DNA