Pathophysiology of Non Alcoholic Fatty Liver Disease

Int J Mol Sci. 2016 Dec 11;17(12):2082. doi: 10.3390/ijms17122082.


The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

Keywords: adiponectin; cholesterol; fatty liver; free fatty acids; ghrelin; glucagon; glucagon-like peptide 1; insulin; insulin resistance; irisin; leptin; selenoprotein P.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Gastrointestinal Hormones / metabolism
  • Humans
  • Lipids / blood
  • Muscles / metabolism
  • Non-alcoholic Fatty Liver Disease / blood
  • Non-alcoholic Fatty Liver Disease / physiopathology*
  • Pancreatic Hormones / metabolism


  • Gastrointestinal Hormones
  • Lipids
  • Pancreatic Hormones