Salmonella-induced inflammasome activation in humans

Mol Immunol. 2017 Jun;86:38-43. doi: 10.1016/j.molimm.2016.11.009. Epub 2016 Dec 11.

Abstract

Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.

Keywords: Caspase; Inflammasome; NOD-like receptor; Salmonella; Toll-like receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Caspases / metabolism
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Innate
  • Inflammasomes / immunology*
  • Inflammasomes / metabolism
  • Interleukin-18 / metabolism
  • Interleukin-1beta / metabolism
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / microbiology
  • Macrophages / immunology
  • Mice
  • NLR Proteins / metabolism
  • Pathogen-Associated Molecular Pattern Molecules / immunology
  • Pyroptosis
  • Salmonella Infections / immunology*
  • Salmonella Infections / pathology
  • Salmonella typhimurium / immunology*
  • Salmonella typhimurium / pathogenicity
  • Signal Transduction
  • Toll-Like Receptors / metabolism

Substances

  • Inflammasomes
  • Interleukin-18
  • Interleukin-1beta
  • NLR Proteins
  • Pathogen-Associated Molecular Pattern Molecules
  • Toll-Like Receptors
  • Caspases