Local intraarterial fibrinolysis in acute vertebrobasilar occlusion. Technical developments and recent results

Neuroradiology. 1989;31(4):336-40. doi: 10.1007/BF00344178.


Local intraarterial fibrinolytic therapy (LIF) in patients with acute vertebrobasilar occlusion (AVBO) is a rational and if successful a life saving treatment. The recent progress in this field is determined by the use of microcatheters for superselective basilar artery catheterisation and a "short time, highdose" regimen using 750.000 IU Urokinase in not more than two h. Two out of 7 patients died and 1 did not improve to a better than a locked-in-state. Four patients however survived with excellent outcome.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Basilar Artery / diagnostic imaging
  • Humans
  • Infusions, Intra-Arterial
  • Methods
  • Middle Aged
  • Prognosis
  • Radiography
  • Retrospective Studies
  • Time Factors
  • Urokinase-Type Plasminogen Activator / administration & dosage*
  • Urokinase-Type Plasminogen Activator / therapeutic use
  • Vertebral Artery / diagnostic imaging
  • Vertebrobasilar Insufficiency / diagnostic imaging
  • Vertebrobasilar Insufficiency / drug therapy*


  • Urokinase-Type Plasminogen Activator