Bacterial Proteasomes: Mechanistic and Functional Insights

Microbiol Mol Biol Rev. 2016 Dec 14;81(1):e00036-16. doi: 10.1128/MMBR.00036-16. Print 2017 Mar.


Regulated proteolysis is essential for the normal physiology of all organisms. While all eukaryotes and archaea use proteasomes for protein degradation, only certain orders of bacteria have proteasomes, whose functions are likely as diverse as the species that use them. In this review, we discuss the most recent developments in the understanding of how proteins are targeted to proteasomes for degradation, including ATP-dependent and -independent mechanisms, and the roles of proteasome-dependent degradation in protein quality control and the regulation of cellular physiology. Furthermore, we explore newly established functions of proteasome system accessory factors that function independently of proteolysis.

Keywords: proteasome.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Archaea / metabolism*
  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteolysis*


  • Bacterial Proteins
  • Adenosine Triphosphate
  • Proteasome Endopeptidase Complex