Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Nanoscale. 2017 Jan 5;9(2):764-773. doi: 10.1039/c6nr07520g.


Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

MeSH terms

  • Astrocytes / cytology
  • Blood-Brain Barrier*
  • Brain / cytology
  • Brain / diagnostic imaging*
  • Cells, Cultured
  • Endothelial Cells / cytology
  • Gold
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetics
  • Magnetite Nanoparticles*
  • Models, Biological
  • Multimodal Imaging*


  • Magnetite Nanoparticles
  • Gold