Abstract
2-Amino-2-(trifluoromethoxy)butanoic acid (O-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured pKa and log D values establish the compound as a promising analogue of natural aliphatic amino acids.
MeSH terms
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry*
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Butyrates / chemical synthesis*
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Butyrates / chemistry*
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Chemistry, Physical
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Hydrocarbons, Fluorinated / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Models, Molecular
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Molecular Structure
Substances
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2-amino-4-(trifluoromethoxy)butanoic acid
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Amino Acids
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Butyrates
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Hydrocarbons, Fluorinated