Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?

J Glaucoma. 2018 Mar;27(3):197-201. doi: 10.1097/IJG.0000000000000606.

Abstract

In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy / physiology*
  • Exfoliation Syndrome / etiology*
  • Exfoliation Syndrome / metabolism
  • Exfoliation Syndrome / pathology
  • Female
  • Fibroblasts / metabolism
  • Fibroblasts / pathology
  • Fibroblasts / physiology
  • Glaucoma / etiology*
  • Glaucoma / metabolism
  • Glaucoma / pathology
  • Humans
  • Intraocular Pressure / physiology
  • Male
  • Tenon Capsule / metabolism
  • Tenon Capsule / pathology