HSV1 Pulls the Deamidation tRIGger

Cell Host Microbe. 2016 Dec 14;20(6):698-700. doi: 10.1016/j.chom.2016.11.011.

Abstract

Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. In this issue of Cell Host & Microbe, Zhao et al. (2016b) reveal a viral strategy to inactivate RIG-I signaling that relies on deamidation of RIG-I.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • DEAD Box Protein 58 / immunology*
  • Herpes Simplex / immunology
  • Herpesvirus 1, Human / immunology*
  • Immunity, Innate*
  • Interferon Regulatory Factor-3 / metabolism
  • Interferon Regulatory Factor-7 / metabolism
  • NF-kappa B / metabolism
  • Polyubiquitin / pharmacology
  • Receptors, Immunologic
  • Signal Transduction / immunology*
  • TNF Receptor-Associated Factor 6 / metabolism
  • Viral Structural Proteins / immunology

Substances

  • IRF3 protein, human
  • IRF7 protein, human
  • Interferon Regulatory Factor-3
  • Interferon Regulatory Factor-7
  • NF-kappa B
  • Receptors, Immunologic
  • TNF Receptor-Associated Factor 6
  • UL37 protein, Human herpesvirus 1
  • Viral Structural Proteins
  • Polyubiquitin
  • Adenosine Triphosphate
  • RIGI protein, human
  • DEAD Box Protein 58