The Hyperfiltering Kidney in Diabetes

Nephron. 2017;136(4):277-280. doi: 10.1159/000448183. Epub 2016 Dec 16.

Abstract

Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes.

Keywords: Diabetes; Diabetic nephropathy; Hyperfiltration; Intraglomerular pressure.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Nephropathies / drug therapy
  • Diabetic Nephropathies / physiopathology*
  • Disease Progression
  • Glomerular Filtration Rate*
  • Humans
  • Kidney / physiopathology*
  • Sodium-Glucose Transporter 2
  • Sodium-Glucose Transporter 2 Inhibitors

Substances

  • SLC5A2 protein, human
  • Sodium-Glucose Transporter 2
  • Sodium-Glucose Transporter 2 Inhibitors