Visible-Light-Induced Photocatalytic Aerobic Oxidative Csp3-H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

Xiaorong Yang; Liqi Li; Ying Li; Yuan Zhang

doi:10.1021/acs.joc.6b02683

Visible-Light-Induced Photocatalytic Aerobic Oxidative C_sp3-H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

J Org Chem. 2016 Dec 16;81(24):12433-12442. doi: 10.1021/acs.joc.6b02683. Epub 2016 Nov 30.

Authors

Xiaorong Yang¹, Liqi Li¹, Ying Li¹, Yuan Zhang¹

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , 222 Tianshui South Road, Lanzhou 730000, PR China.

PMID: 27978716
DOI: 10.1021/acs.joc.6b02683

Abstract

A visible-light induced photocatalytic aerobic oxidative dehydrogenative coupling/aromatization tandem reaction of glycine esters with unactivated alkenes has been accomplished. This visible light-driven protocol has been successfully applied to a broad scope of glycine esters and simple alkenes, giving rise to diverse substituted quinoline derivatives in 18-84% yield under mild (at room temperature under air atmosphere) and operationally simple reaction conditions.

Publication types

Research Support, Non-U.S. Gov't