Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis

Haematologica. 2017 Mar;102(3):e89-e92. doi: 10.3324/haematol.2016.155978. Epub 2016 Dec 15.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adenine / analogs & derivatives
  • Adenosine Diphosphate / pharmacology
  • Animals
  • Blood Platelets / cytology
  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Collagen / pharmacology
  • Crotalid Venoms / pharmacology
  • Gene Expression Regulation
  • Hemorrhage / drug therapy*
  • Hemorrhage / genetics
  • Hemorrhage / metabolism
  • Hemorrhage / pathology
  • Hemostasis / drug effects*
  • Inflammation / prevention & control
  • Lectins, C-Type / genetics
  • Lectins, C-Type / metabolism
  • Lipopolysaccharides / pharmacology
  • Lung / drug effects
  • Lung / metabolism
  • Lung / pathology
  • Membrane Glycoproteins / pharmacology
  • Mice
  • Oligopeptides / pharmacology
  • Piperidines
  • Platelet Aggregation / drug effects*
  • Platelet Membrane Glycoproteins / agonists
  • Platelet Membrane Glycoproteins / genetics
  • Platelet Membrane Glycoproteins / metabolism
  • Protein Kinase Inhibitors / pharmacology*
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*
  • Receptors, Purinergic P2Y12 / deficiency
  • Receptors, Purinergic P2Y12 / genetics
  • Receptors, Purinergic P2Y12 / metabolism
  • Skin / drug effects
  • Skin / metabolism
  • Skin / pathology

Substances

  • CLEC-2 protein, mouse
  • Crotalid Venoms
  • Gp38 protein, mouse
  • Lectins, C-Type
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Oligopeptides
  • P2ry12 protein, mouse
  • Piperidines
  • Platelet Membrane Glycoproteins
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyrimidines
  • Receptors, Purinergic P2Y12
  • alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine
  • platelet membrane glycoprotein VI
  • ibrutinib
  • convulxin
  • Adenosine Diphosphate
  • Collagen
  • Adenine