[Broncho-alveolar Lavage by Fibroscopy in Immunodepressed Children]

Pediatrie. 1989;44(1):45-51.
[Article in French]

Abstract

Thirty broncho-alveolar lavage (BAL) were performed in order to investigate 30 infectious episodes in immunocompromised children. Twenty patients were previously treated by high-dose chemotherapy and autologous bone marrow transplantation and 6 other patients by conventional methods. A specific etiologic diagnosis was obtained in 16 of 30 episodes (56%), 22 microorganisms were identified by BAL. The most frequently involved microorganism was Candida albicans and the other agents were as follows: 3 cytomegalovirus, 2 Pneumococcus, 2 Pneumocystis carinii, 1 Aspergillosis, 1 syncytial respiratory virus, 1 myxovirus, 1 Pseudomonas aeruginosa, 1 Mycoplasma pneumoniae, 1 Haemophilus influenzae and 1 Escherichia coli. In 5 cases, more than 2 agents were involved. This study emphasizes the diagnostic interest of BAL for infectious diseases of the immunocompromised child. BAL appears to be a non invasive, rapid and reproducible method, and a useful therapeutic approach in the treatment of infectious episodes occurring in grafted children where several microorganisms could be involved at the same time.

MeSH terms

  • Bacterial Infections / diagnostic imaging
  • Bacterial Infections / etiology
  • Bone Marrow Transplantation*
  • Bronchoalveolar Lavage Fluid / pathology
  • Bronchoscopy / methods*
  • Child
  • Child, Preschool
  • Female
  • Fiber Optic Technology
  • Humans
  • Immune Tolerance*
  • Infant
  • Male
  • Mycoses / diagnostic imaging
  • Mycoses / etiology
  • Postoperative Complications / diagnostic imaging*
  • Radiography
  • Therapeutic Irrigation
  • Transplantation, Autologous
  • Virus Diseases / diagnostic imaging
  • Virus Diseases / etiology