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Randomized Controlled Trial
. 2016 Dec 5;18(4):463-468.
doi: 10.11152/mu-874.

Intra-articular Hyaluronic Acid vs Platelet-Rich Plasma in the Treatment of Hip Osteoarthritis

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Free article
Randomized Controlled Trial

Intra-articular Hyaluronic Acid vs Platelet-Rich Plasma in the Treatment of Hip Osteoarthritis

Luca Di Sante et al. Med Ultrason. .
Free article

Abstract

Aim: To compare the efficacy of ultrasound-guided intra-articular (IA) treatment with platelet-rich plasma (PRP) versus viscosupplementation (hyaluronic acid HA) in hip osteoarthritis. METHODS: A total of 43 patients affected by monolateral severe hip osteoarthritis (OA) were included in the study. Patients were randomized to receive either intra-articular PRP (3 ml) or HA (30 mg/2 ml; 1,000-2,900 kDa), 3 injections in total - 1/week. Clinical assessments for each patient were made at baseline (T0), 4 (T1), and 16 weeks (T2) of follow-up. The primary efficacy outcome was pain reduction as measured by VAS and by WOMAC pain subscale.

Results: Data analysis revealed that, compared to T0, in the PRP-treated group VAS scores significantly decreased at T1 but not at T2, thereby indicating an early effect on pain which was not maintained at a longer term follow-up. In the HA group a significant decrease of both VAS and WOMAC values was registered only between T0 and T2.

Conclusions: Intra-articular PRP had an immediate effect on pain that was not maintained at longer term follow-up when, on the contrary, the effects of intra-articular HA were evident.

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