A Zygotic Checkpoint for Unrepaired Lesions

Cell. 2016 Dec 15;167(7):1676-1678. doi: 10.1016/j.cell.2016.11.049.


DNA demethylation, a process involving DNA repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition. A new study by Ladstätter and Tachibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrepaired lesions from entering mitosis.

Publication types

  • Comment

MeSH terms

  • Cell Cycle Checkpoints
  • DNA Methylation*
  • DNA Repair
  • Genome
  • Humans
  • Zygote / metabolism*