Back to the Roots: Deep View into the Evolutionary History of ADP-Ribosylation Opened by the DNA-Targeting Toxin-Antitoxin Module DarTG

Mol Cell. 2016 Dec 15;64(6):1020-1021. doi: 10.1016/j.molcel.2016.11.038.

Abstract

In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

Keywords: ADP-ribosylation; DarG; DarT; bacterial persistence; restriction-modification system; toxin-antitoxin module.

Publication types

  • Comment

MeSH terms

  • Adenosine Diphosphate
  • Adenosine Diphosphate Ribose
  • Adenylate Cyclase Toxin
  • Antitoxins*
  • DNA
  • DNA, Single-Stranded*
  • Humans

Substances

  • Adenylate Cyclase Toxin
  • Antitoxins
  • DNA, Single-Stranded
  • Adenosine Diphosphate Ribose
  • Adenosine Diphosphate
  • DNA