Prevention and management of glucocorticoid-induced side effects: A comprehensive review: Gastrointestinal and endocrinologic side effects

J Am Acad Dermatol. 2017 Jan;76(1):11-16. doi: 10.1016/j.jaad.2016.02.1239.


Part 2 of this 4-part continuing medical education series continues with a discussion of the prevention and management of gastrointestinal side effects associated with corticosteroid use, including peptic ulcer disease, gastrointestinal bleeding, and pancreatitis, followed by a review of corticosteroid-related endocrinologic side effects, such as diabetes, adrenal suppression, and Cushing syndrome.

Keywords: Cushing syndrome; adrenal suppression; diabetes; gastrointestinal bleeding; glucocorticoids; peptic ulcer disease; side effects; steroids.

Publication types

  • Review

MeSH terms

  • Adrenal Glands / drug effects
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Blood Glucose Self-Monitoring
  • Cushing Syndrome / chemically induced
  • Cushing Syndrome / therapy
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / chemically induced*
  • Diabetes Mellitus / drug therapy*
  • Drug Therapy, Combination / adverse effects
  • Gastrointestinal Hemorrhage / chemically induced*
  • Glucocorticoids / adverse effects*
  • Humans
  • Pancreatitis / chemically induced
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / prevention & control*
  • Proton Pump Inhibitors / therapeutic use


  • Anti-Inflammatory Agents, Non-Steroidal
  • Glucocorticoids
  • Proton Pump Inhibitors