Oocyte Competence in Women with Polycystic Ovary Syndrome

Trends Endocrinol Metab. 2017 Mar;28(3):186-198. doi: 10.1016/j.tem.2016.11.008. Epub 2016 Dec 14.


Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation induction is often used to treat anovulatory patients with PCOS, but many of these women fail to conceive and resort to assisted reproductive technologies. Alterations in oocyte competence (OC) are considered potential causative factors for subfertility in women with PCOS. In this review we present and critically assess all recent clinical and experimental data regarding OC in women with PCOS. Our analysis demonstrates that the contribution of OC to reproductive potential in women with PCOS varies and largely depends on the PCOS phenotype and comorbidities associated with PCOS.

Keywords: PCOS; competence; fertility; infertility; oocyte; quality.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Infertility, Female / physiopathology
  • Oocytes / cytology*
  • Oocytes / physiology
  • Ovulation Induction
  • Polycystic Ovary Syndrome / pathology
  • Polycystic Ovary Syndrome / physiopathology*
  • Pregnancy