Probiotics and Prevention of Clostridium Difficile Infection

Anaerobe. 2017 Jun;45:114-119. doi: 10.1016/j.anaerobe.2016.12.007. Epub 2016 Dec 14.


The role of probiotics as adjunctive measures in the prevention of Clostridium difficile infection (CDI) has been controversial. However, a growing body of evidence has suggested that they have a role in primary prevention of CDI. Elements of this controversy are reviewed and the proposed mechanisms of action, the value and cost effectiveness of probiotics are addressed with a focus on three agents, Saccharomyces boulardii, Lactobacillus rhamnosus GG and the combination of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, Lactobacillus rhamnosus CLR2 (Bio-K+).

Keywords: Bio-K+; C. difficile; Lactobacillus acidophilus CL1285; Lactobacillus casei LBC80R; Lactobacillus rhamnosus CLR2; Lactobacillus rhamnosus GG; Probiotic; Saccharomyces boulardii.

Publication types

  • Review

MeSH terms

  • Clostridium Infections / economics
  • Clostridium Infections / prevention & control*
  • Cost-Benefit Analysis
  • Humans
  • Lactobacillus acidophilus / growth & development
  • Lactobacillus casei / growth & development
  • Lactobacillus rhamnosus / growth & development
  • Probiotics / administration & dosage*
  • Probiotics / economics
  • Saccharomyces boulardii / growth & development