The role of probiotics as adjunctive measures in the prevention of Clostridium difficile infection (CDI) has been controversial. However, a growing body of evidence has suggested that they have a role in primary prevention of CDI. Elements of this controversy are reviewed and the proposed mechanisms of action, the value and cost effectiveness of probiotics are addressed with a focus on three agents, Saccharomyces boulardii, Lactobacillus rhamnosus GG and the combination of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, Lactobacillus rhamnosus CLR2 (Bio-K+).
Keywords: Bio-K+; C. difficile; Lactobacillus acidophilus CL1285; Lactobacillus casei LBC80R; Lactobacillus rhamnosus CLR2; Lactobacillus rhamnosus GG; Probiotic; Saccharomyces boulardii.
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