The development of non-coding RNA ontology

Int J Data Min Bioinform. 2016;15(3):214-232. doi: 10.1504/IJDMB.2016.077072.


Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data.

Keywords: bio-ontologies; domain ontology; non-coding RNA; ontology development; reference ontology; semantic data annotation.