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. 2017 Mar;61(3).
doi: 10.1002/mnfr.201600471. Epub 2016 Dec 19.

Curcumin Improves Glucose Tolerance via Stimulation of Glucagon-Like peptide-1 Secretion

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Curcumin Improves Glucose Tolerance via Stimulation of Glucagon-Like peptide-1 Secretion

Masaki Kato et al. Mol Nutr Food Res. .

Abstract

Scope: Glucagon-like peptide-1 (GLP-1) is a type of incretin secreted from enteroendocrine L-cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP-1 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin-induced GLP-1 secretion has not been clarified.

Methods and results: Glucose tolerance was significantly improved in rats after pre-administered curcumin (1.5 mg/kg) followed by intraperitoneal glucose injections via the stimulation of GLP-1 secretion and the induction of insulin secretion. In GLUTag cells, curcumin-induced GLP-1 secretion was associated with G protein-coupled receptor (GPR) 40/120. Furthermore, the glucose-lowering effect induced by curcumin was significantly reduced after the administration of a GPR40/120 antagonist in rats.

Conclusion: These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.

Keywords: Curcumin; Diabetes; G protein-coupled receptor 40/120; Glucagon-like peptide-1; Glucose tolerance.

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