Online Hemodiafiltration Reduces Bisphenol A Levels

Ther Apher Dial. 2017 Feb;21(1):96-101. doi: 10.1111/1744-9987.12475. Epub 2016 Dec 20.


Several uremic toxins have been identified and related to higher rates of morbidity and mortality in dialysis patients. Bisphenol A (BPA) accumulates in patients with chronic kidney disease. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OL-HDF) in reducing BPA levels. Thirty stable hemodialysis patients were selected to participate in this paired study. During three periods of 3 weeks each, patients were switched from high-flux hemodialysis (HF-HD) to OL-HDF, and back to HF-HD. BPA levels were measured in the last session of each period (pre- and post-dialysis) using ELISA and HPLC. Twenty-two patients (mean age 73 ± 14 years; 86.4% males) were included. Measurements of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r = 0.218, P = 0.012). BPA levels decreased in the OL-HDF period of hemodialysis, in contrast to the HF-HD period when they remained stable (P = 0.002). In conclusion, OL-HDF reduced BPA levels in dialysis patients.

Keywords: Bisphenol A; Hemodialysis; Online hemodiafiltration; Uremic toxins.

MeSH terms

  • Aged
  • Benzhydryl Compounds / blood*
  • Chromatography, High Pressure Liquid
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hemodiafiltration / methods*
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / therapy*
  • Male
  • Phenols / blood*
  • Prospective Studies


  • Benzhydryl Compounds
  • Phenols
  • bisphenol A