Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies

Cancer Invest. 2017 Jan 2;35(1):1-22. doi: 10.1080/07357907.2016.1247166. Epub 2016 Dec 20.


Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways. Curcumin is a promising molecule for the prevention and treatment of cancer.

Keywords: Apoptosis; Bioavailability; Chemotherapy; Curcumin; Synergistic effect.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biological Availability
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Clinical Trials as Topic
  • Curcumin / analogs & derivatives*
  • Curcumin / pharmacokinetics*
  • Curcumin / therapeutic use
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Neoplasm Invasiveness
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / prevention & control
  • Signal Transduction / drug effects


  • Antineoplastic Agents
  • Curcumin