Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

Abstract

Errors in chromosome segregation during mitosis have been recognized as a hallmark of tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic abnormalities drive tumorigenesis. Recent work has shown that mitotic defects can promote tumors, suppress them, or do neither, depending on the rate of chromosome missegregation. Here we discuss the causes of chromosome missegregation, their effects on tumor initiation and progression, and the evidence that increasing the rate of chromosome missegregation may be an effective chemotherapeutic strategy.

Keywords: CIN; aneuploidy; chromosomal instability; mitosis; mitotic checkpoint; spindle assembly checkpoint.