MRSA in persons not living or working on a farm in a livestock-dense area: prevalence and risk factors

J Antimicrob Chemother. 2017 Mar 1;72(3):893-899. doi: 10.1093/jac/dkw483.

Abstract

Objectives: MRSA emerged in livestock and persons in contact with livestock is referred to as livestock-associated MRSA (LA-MRSA). We assessed the prevalence and risk factors for MRSA carriage in persons not living or working on a farm.

Methods: A cross-sectional study was performed among 2492 adults living in close proximity of livestock farms. Persons working and/or living on farms were excluded. Nasal swabs were cultured using selective media. Participants completed questionnaires and the distance from the residential address to the nearest farm was calculated. The Mann-Whitney U -test was used to compare median distances. Risk factors were explored with logistic regression.

Results: Fourteen persons carried MRSA (0.56%; 95% CI 0.32%-0.92%), 10 of which carried LA-MRSA of multiple-locus variable-number tandem repeat analysis complex (MC) 398 (0.40%; 95% CI 0.20%-0.71%). MRSA MC 398 carriers lived significantly closer to the nearest farm than non-carriers (median: 184 versus 402 m; P < 0.01). In bivariate analyses correcting for contact with livestock, this difference remained significant.

Conclusions: Although the prevalence was low, living near farms increased the risk of MRSA MC 398 carriage for persons not living or working on a farm. Further research is necessary to identify the transmission routes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Agriculture
  • Animals
  • Carrier State / epidemiology*
  • Carrier State / microbiology
  • Cross-Sectional Studies
  • Farms
  • Female
  • Humans
  • Livestock / microbiology
  • Logistic Models
  • Male
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Nose / microbiology
  • Prevalence
  • Risk Factors
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / transmission
  • Surveys and Questionnaires