Carbamazepine-induced angioedema

J Basic Clin Pharm. 2016 Sep;7(4):120-122. doi: 10.4103/0976-0105.189436.


Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and with the withdrawal of carbamazepine, the offending drug. Carbamazepine-induced angioedema is a life-threatening reaction which requires immediate treatment and monitoring in order to avoid morbidity and mortality.

Keywords: Angioedema; antiepileptic drug; carbamazepine; cutaneous reaction.

Publication types

  • Case Reports