Neonatal Bacterial Conjunctivitis in Korea in the 21st Century

Cornea. 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122.


Purpose: To investigate the microbial cause and antibiotic susceptibility of neonatal bacterial conjunctivitis in Korean patients in the 21st century.

Methods: We retrospectively reviewed the medical records of patients diagnosed with neonatal bacterial conjunctivitis between January 2000 and December 2015. We recorded the organism, antibiotic susceptibility, and antibiotics used.

Results: A total of 82 neonates were included in the study (53 males and 29 females), with a mean age of 17.5 ± 7.1 days. The most commonly isolated organisms were Staphylococcus aureus (43 cases, 52.4%), coagulase-negative staphylococci (11 cases, 13.4%), Staphylococcus epidermidis (11 cases, 13.4%), Serratia marcescens (4 cases, 4.9%), Pseudomonas aeruginosa (4 cases, 4.9%), and Enterobacter cloacae (3 cases, 3.7%). We found no cases of Neisseria gonorrhoeae or Chlamydia trachomatis infection. Resistance to methicillin (83.7%), macrolide (81.4%), and aminoglycoside (23.3%) was observed in patients with S. aureus infection. Conjunctivitis that did not improve with erythromycin or tobramycin generally improved with the additional use of tosufloxacin.

Conclusions: The prevalence of neonatal gonococcal or chlamydial conjunctivitis has decreased in the 21st century. However, methicillin-resistant S. aureus has been increasing, but these cases are responsive to tosufloxacin.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / drug effects
  • Bacteria / isolation & purification*
  • Coinfection
  • Conjunctivitis, Bacterial / drug therapy
  • Conjunctivitis, Bacterial / epidemiology
  • Conjunctivitis, Bacterial / microbiology*
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / epidemiology
  • Eye Infections, Bacterial / microbiology*
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Prevalence
  • Republic of Korea / epidemiology
  • Retrospective Studies


  • Anti-Bacterial Agents