Immune Cell Intolerance for Excess Cholesterol

Immunity. 2016 Dec 20;45(6):1186-1188. doi: 10.1016/j.immuni.2016.12.006.


Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c+ immune cells result in impaired antigen presentation and ultimately in autoimmune disease.

Publication types

  • Comment

MeSH terms

  • Antigen Presentation*
  • Autoimmune Diseases
  • Cholesterol*
  • Humans


  • Cholesterol

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