Anaplastic large cell lymphoma masquerading as osteomyelitis of the shoulder: an uncommon presentation

BMJ Case Rep. 2016 Dec 21:2016:bcr2016217317. doi: 10.1136/bcr-2016-217317.

Abstract

The presentation of anaplastic lymphoma kinase protein (ALK)-negative anaplastic large cell lymphoma (ALCL) in bone is rare. We describe a patient with ALK-negative ALCL presenting with clinical and radiographic findings suggesting osteomyelitis 6 months after left rotator cuff repair surgery. A review of the characteristics of ALK-negative ALCL with primary bone involvement is presented. ALCL should be considered in patients not responding to therapies for osteomyelitis.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / drug therapy
  • Cyclophosphamide / therapeutic use
  • Diagnosis, Differential
  • Doxorubicin / therapeutic use
  • Etoposide / therapeutic use
  • Humans
  • Lymphatic Metastasis
  • Lymphoma, Large-Cell, Anaplastic / diagnosis*
  • Lymphoma, Large-Cell, Anaplastic / drug therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multimodal Imaging
  • Osteomyelitis / diagnosis*
  • Positron Emission Tomography Computed Tomography
  • Prednisone / therapeutic use
  • Shoulder
  • Skin Neoplasms / secondary
  • Vincristine / therapeutic use

Substances

  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • EPOCH protocol