Chronic Inflammation: Accelerator of Biological Aging

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1218-1225. doi: 10.1093/gerona/glw240.


Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named "inflamm-aging" and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer's disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.

Keywords: aging; biology; chronic diseases; inflammation.

Publication types

  • Review
  • Retracted Publication

MeSH terms

  • Aging / physiology*
  • Biomarkers
  • Chronic Disease
  • Humans
  • Inflammation / physiopathology*
  • Morbidity
  • Risk Factors


  • Biomarkers