Elementary proof of convergence to the mean-field model for the SIR process

J Math Biol. 2017 Aug;75(2):327-339. doi: 10.1007/s00285-016-1086-1. Epub 2016 Dec 21.

Abstract

The susceptible-infected-recovered (SIR) model has been used extensively to model disease spread and other processes. Despite the widespread usage of this ordinary differential equation (ODE) based model which represents the mean-field approximation of the underlying stochastic SIR process on contact networks, only few rigorous approaches exist and these use complex semigroup and martingale techniques to prove that the expected fraction of the susceptible and infected nodes of the stochastic SIR process on a complete graph converges as the number of nodes increases to the solution of the mean-field ODE model. Extending the elementary proof of convergence for the SIS process introduced by Armbruster and Beck (IMA J Appl Math, doi: 10.1093/imamat/hxw010 , 2016) to the SIR process, we show convergence using only a system of three ODEs, simple probabilistic inequalities, and basic ODE theory. Our approach can also be generalized to many other types of compartmental models (e.g., susceptible-infected-recovered-susceptible (SIRS)) which are linear ODEs with the addition of quadratic terms for the number of new infections similar to the SI term in the SIR model.

Keywords: Epidemic; Markov chain; Mean-field ODE; Mean-square convergence; SIR.

MeSH terms

  • Algorithms
  • Communicable Disease Control
  • Communicable Diseases / epidemiology*
  • Computer Simulation
  • Disease Susceptibility
  • Epidemics / statistics & numerical data*
  • Humans
  • Models, Biological*
  • Stochastic Processes