Noninvasive IDH1 mutation estimation based on a quantitative radiomics approach for grade II glioma

Eur Radiol. 2017 Aug;27(8):3509-3522. doi: 10.1007/s00330-016-4653-3. Epub 2016 Dec 21.


Objective: The status of isocitrate dehydrogenase 1 (IDH1) is highly correlated with the development, treatment and prognosis of glioma. We explored a noninvasive method to reveal IDH1 status by using a quantitative radiomics approach for grade II glioma.

Methods: A primary cohort consisting of 110 patients pathologically diagnosed with grade II glioma was retrospectively studied. The radiomics method developed in this paper includes image segmentation, high-throughput feature extraction, radiomics sequencing, feature selection and classification. Using the leave-one-out cross-validation (LOOCV) method, the classification result was compared with the real IDH1 situation from Sanger sequencing. Another independent validation cohort containing 30 patients was utilised to further test the method.

Results: A total of 671 high-throughput features were extracted and quantized. 110 features were selected by improved genetic algorithm. In LOOCV, the noninvasive IDH1 status estimation based on the proposed approach presented an estimation accuracy of 0.80, sensitivity of 0.83 and specificity of 0.74. Area under the receiver operating characteristic curve reached 0.86. Further validation on the independent cohort of 30 patients produced similar results.

Conclusions: Radiomics is a potentially useful approach for estimating IDH1 mutation status noninvasively using conventional T2-FLAIR MRI images. The estimation accuracy could potentially be improved by using multiple imaging modalities.

Key points: • Noninvasive IDH1 status estimation can be obtained with a radiomics approach. • Automatic and quantitative processes were established for noninvasive biomarker estimation. • High-throughput MRI features are highly correlated to IDH1 states. • Area under the ROC curve of the proposed estimation method reached 0.86.

Keywords: Grade II glioma; Isocitrate dehydrogenase 1; Magnetic resonance imaging; Noninvasive biomarker estimation; Radiomics.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / genetics
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Glioma / diagnostic imaging
  • Glioma / genetics*
  • Glioma / pathology
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Infant
  • Infant, Newborn
  • Isocitrate Dehydrogenase / genetics*
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Mutation*
  • Neoplasm Grading
  • Neoplasm Proteins / genetics
  • Prognosis
  • ROC Curve
  • Retrospective Studies
  • Sensitivity and Specificity
  • Young Adult


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Isocitrate Dehydrogenase
  • IDH1 protein, human