Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?

Bioessays. 2017 Jan;39(1):1-11. doi: 10.1002/bies.201600179. Epub 2016 Nov 7.

Abstract

We propose that the essential function of the most highly conserved protein in bacterial cytokinesis, FtsZ, is not to generate a mechanical force to drive cell division. Rather, we suggest that FtsZ acts as a signal-processing hub to coordinate cell wall synthesis at the division septum with a diverse array of cellular processes, ensuring that the cell divides smoothly at the correct time and place, and with the correct septum morphology. Here, we explore how the polymerization properties of FtsZ, which have been widely attributed to force generation, can also be advantageous in this signal processing role. We suggest mechanisms by which FtsZ senses and integrates both mechanical and biochemical signals, and conclude by proposing experiments to investigate how FtsZ contributes to the remarkable spatial and temporal precision of bacterial cytokinesis.

Keywords: FtsZ; cell division; cell wall synthesis; cytokinesis; cytoskeleton; dynamics; force generation; signaling.

Publication types

  • Review

MeSH terms

  • Bacteria / metabolism*
  • Bacterial Physiological Phenomena*
  • Bacterial Proteins / metabolism*
  • Bacterial Proteins / physiology
  • Cytokinesis*
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeletal Proteins / physiology

Substances

  • Bacterial Proteins
  • Cytoskeletal Proteins
  • FtsZ protein, Bacteria