Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus

Nat Commun. 2016 Dec 22:7:13721. doi: 10.1038/ncomms13721.


Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Cyanates / pharmacology
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism
  • Hippocampus / physiology*
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Olfactory Cortex / physiology*
  • Olfactory Pathways / drug effects
  • Olfactory Pathways / physiology
  • Optogenetics
  • Red Fluorescent Protein
  • Smell / physiology*


  • Bacterial Proteins
  • Cyanates
  • Luminescent Proteins
  • yellow fluorescent protein, Bacteria
  • Green Fluorescent Proteins