Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 51 (2), 91-99

The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders

Affiliations
Review

The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders

Adam D Farmer et al. J Clin Gastroenterol.

Abstract

The Rome IV diagnostic criteria delineates 5 functional esophageal disorders which include functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional dysphagia. These are a heterogenous group of disorders which, despite having characteristic symptom profiles attributable to esophageal pathology, fail to demonstrate any structural, motility or inflammatory abnormalities on standard clinical testing. These disorders are associated with a marked reduction in patient quality of life, not least considerable healthcare resources. Furthermore, the pathophysiology of these disorders is incompletely understood. In this narrative review we provide the reader with an introductory primer to the structure and function of esophageal perception, including nociception that forms the basis of the putative mechanisms that may give rise to symptoms in functional esophageal disorders. We also discuss the provocative techniques and outcome measures by which esophageal hypersensitivity can be established.

Similar articles

  • Ineffective Oesophageal Motility: Manometric Subsets Exhibit Different Symptom Profiles
    HG Haack et al. World J Gastroenterol 14 (23), 3719-24. PMID 18595138.
    IOM patients with LASC exhibit a different symptom profile to those with LAP, but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibil …
  • How to Use Rome IV Criteria in the Evaluation of Esophageal Disorders
    M Schmulson. Curr Opin Gastroenterol 34 (4), 258-265. PMID 29846258. - Review
    The esophageal DGBI comprise functional esophageal chest pain, functional heartburn, globus, functional dysphagia, and the newly introduced reflux hypersensitivity. They …
  • Esophageal Hypermotility: Cause or Effect?
    OM Crespin et al. Dis Esophagus 29 (5), 497-502. PMID 25893778.
    Nutcracker esophagus (NE), Jackhammer esophagus (JHE), distal esophageal spasm (DES), and hypertensive lower esophageal sphincter (HTLES) are defined by esophageal manome …
  • The Role of Esophageal Hypersensitivity in Functional Heartburn
    T Kondo et al. J Clin Gastroenterol 51 (7), 571-578. PMID 28682989. - Review
    Functional heartburn (FH) is defined as a functional esophageal disorder characterized by symptoms of chronic heartburn with no apparent correlation to acid or nonacid re …
  • Functional Esophageal Disorders
    JP Galmiche et al. Gastroenterology 130 (5), 1459-65. PMID 16678559. - Review
    Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by struct …
See all similar articles

Cited by 9 PubMed Central articles

See all "Cited by" articles

MeSH terms

Feedback