Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

doi:10.1016/j.jaci.2016.11.020

. 2017 Jul;140(1):280-283.e3.

doi: 10.1016/j.jaci.2016.11.020. Epub 2016 Dec 19.

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

Christina Draijer¹, Carian E Boorsma¹, Patricia Robbe², Wim Timens², Machteld N Hylkema², Nick H Ten Hacken³, Maarten van den Berge³, Dirkje S Postma³, Barbro N Melgert⁴

Affiliations

¹ Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³ Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁴ Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: b.n.melgert@rug.nl.

PMID: 28007476
DOI: 10.1016/j.jaci.2016.11.020

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

Christina Draijer et al. J Allergy Clin Immunol. 2017 Jul.

. 2017 Jul;140(1):280-283.e3.

doi: 10.1016/j.jaci.2016.11.020. Epub 2016 Dec 19.

Authors

Christina Draijer¹, Carian E Boorsma¹, Patricia Robbe², Wim Timens², Machteld N Hylkema², Nick H Ten Hacken³, Maarten van den Berge³, Dirkje S Postma³, Barbro N Melgert⁴

Affiliations

¹ Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³ Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁴ Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: b.n.melgert@rug.nl.

PMID: 28007476
DOI: 10.1016/j.jaci.2016.11.020

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Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

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Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

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