Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Mar;38(3):537-545.
doi: 10.3174/ajnr.A5025. Epub 2016 Dec 22.

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

Collaborators, Affiliations
Free PMC article
Multicenter Study

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

E M Palacios et al. AJNR Am J Neuroradiol. .
Free PMC article

Abstract

Background and purpose: Precision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers that minimize the variability of individual patient measurements. The aim of this study was to assess the intersite variability after harmonization of a high-angular-resolution 3T diffusion tensor imaging protocol across 13 scanners at the 11 academic medical centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury multisite study.

Materials and methods: Diffusion MR imaging was acquired from a novel isotropic diffusion phantom developed at the National Institute of Standards and Technology and from the brain of a traveling volunteer on thirteen 3T MR imaging scanners representing 3 major vendors (GE Healthcare, Philips Healthcare, and Siemens). Means of the DTI parameters and their coefficients of variation across scanners were calculated for each DTI metric and white matter tract.

Results: For the National Institute of Standards and Technology diffusion phantom, the coefficients of variation of the apparent diffusion coefficient across the 13 scanners was <3.8% for a range of diffusivities from 0.4 to 1.1 × 10-6 mm2/s. For the volunteer, the coefficients of variations across scanners of the 4 primary DTI metrics, each averaged over the entire white matter skeleton, were all <5%. In individual white matter tracts, large central pathways showed good reproducibility with the coefficients of variation consistently below 5%. However, smaller tracts showed more variability, with the coefficients of variation of some DTI metrics reaching 10%.

Conclusions: The results suggest the feasibility of standardizing DTI across 3T scanners from different MR imaging vendors in a large-scale neuroimaging research study.

Figures

Fig 1
Fig 1
Prototype isotropic diffusion phantom in 3D-printed shell from the National Institute of Standards and Technology (NIST).
Fig 2
Fig 2
ADC measurements obtained across all 13 scanners in TRACK TBI. The measured ADC in units of 10−6 mm2/sec for vials containing 0% – 50% PVP are plotted for each TRACK TBI MR system. The NIST phantom allows for three measures of 0% PVP and two measures of each of the 10–50% PVP concentrations. Data is shown for the central vial (triangle), inner vials (squares) and outer vials (circles) of the phantom.
Fig 3
Fig 3
Global non-normalized DTI parameters and CoV across sites. Note- Red: Siemens; Blue: GE; Green: Phillips. By order of sites, See Table 1.
Fig 4
Fig 4
Graphical representation CoV across all 13 scanners. Coefficient of Variation (%) in orange. Mean non-normalized DTI parameters in grey.

Similar articles

See all similar articles

Cited by 28 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback