ARF1 at the crossroads of podosome construction and function

J Cell Biol. 2017 Jan 2;216(1):13-15. doi: 10.1083/jcb.201611097. Epub 2016 Dec 22.


Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation, maintenance, and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Actins*
  • Cell Membrane
  • Golgi Apparatus
  • Humans
  • Podosomes*
  • Protein Transport


  • Actins