ARF1 at the crossroads of podosome construction and function

J Cell Biol. 2017 Jan 2;216(1):13-15. doi: 10.1083/jcb.201611097. Epub 2016 Dec 22.

Abstract

Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation, maintenance, and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Actins*
  • Cell Membrane
  • Golgi Apparatus
  • Humans
  • Podosomes*
  • Protein Transport

Substances

  • Actins