Y chromothripsis?

Nat Cell Biol. 2016 Dec 23;19(1):12-14. doi: 10.1038/ncb3458.


Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.

MeSH terms

  • Chromatin / metabolism
  • Chromosomes, Human, Y / metabolism*
  • Chromothripsis*
  • DNA End-Joining Repair
  • Humans
  • Micronuclei, Chromosome-Defective
  • Models, Biological


  • Chromatin