The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double-blind, randomized trial

Obesity (Silver Spring). 2017 Jan;25(1):30-38. doi: 10.1002/oby.21671.


Objective: To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.

Methods: Women who had excess weight or obesity were recruited to a randomized, double-blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony-forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual-energy X-ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin-6, interleukin-10, tumor necrosis factor-α, adiponectin, and the antioxidant enzymes activities were analyzed.

Results: In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (-3.40% vs. -5.48%, P = 0.03), waist-height ratio (-3.27% vs. -5.00%, P = 0.02), conicity index (-2.43% vs. -4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. -18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (-16.67% vs. 15.62%, P < 0.01).

Conclusions: Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiposity / drug effects*
  • Adult
  • Antioxidants / administration & dosage*
  • Body Mass Index
  • Diet, Reducing / methods
  • Double-Blind Method
  • Female
  • Humans
  • Obesity, Abdominal / drug therapy*
  • Obesity, Abdominal / prevention & control
  • Probiotics / administration & dosage*


  • Antioxidants