[Enteric microflora in inflammatory bowel disease patients]

Med Sci (Paris). 2016 Nov;32(11):968-973. doi: 10.1051/medsci/20163211012. Epub 2016 Dec 23.
[Article in French]


During the last years, the importance of a well equilibrated intestinal microbiota (eubiosis) has become more and more obvious in human health. Dysbiosis is now a well-recognized feature associated with IBD (inflammatory bowel disease). Rupture of the normal microbiota can occur through different mechanisms: (1) by a typical Western diet rich in fat and low in fiber, (2) by an acute disruption of the microbiota (by an acute gastroenteritis or by intake of antibiotics) or (3) by a combination of event in early childhood avoiding the establishment of eubiosis (the hygiene hypothesis). Risk factors for IBD are stated for each disruption mechanism. Dysbiosis can also induce colonization by several pathobionts able to aggravate inflammation. Among the potential candidates in IBD, most attention has been paid on AIEC during the last years.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / complications
  • Bacterial Infections / immunology
  • Bacterial Infections / microbiology
  • Diet / adverse effects
  • Dysbiosis / genetics
  • Dysbiosis / immunology
  • Dysbiosis / microbiology
  • Gastroenteritis / immunology
  • Gastroenteritis / microbiology
  • Gastrointestinal Microbiome / genetics
  • Gastrointestinal Microbiome / immunology
  • Gastrointestinal Microbiome / physiology*
  • Host-Pathogen Interactions / physiology
  • Humans
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / microbiology*