Ammosamides Unveil Novel Biosynthetic Machinery

Dominic A Colosimo; John B MacMillan

doi:10.1016/j.chembiol.2016.12.001

Ammosamides Unveil Novel Biosynthetic Machinery

Cell Chem Biol. 2016 Dec 22;23(12):1444-1446. doi: 10.1016/j.chembiol.2016.12.001.

Authors

Dominic A Colosimo¹, John B MacMillan²

Affiliations

¹ Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: dominic.colosimo@utsouthwestern.edu.
² Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: john.macmillan@utsouthwestern.edu.

PMID: 28009976
DOI: 10.1016/j.chembiol.2016.12.001

Abstract

In this issue of Cell Chemical Biology, Jordan and Moore (2016) present a thorough biosynthetic analysis of ammosamides, a bacterial natural product. The work highlights the previously unknown overlap between two natural products families: pyrroloquinoline alkaloids and ribosomally synthesized posttranslationally modified peptides (RiPPs).